Treatment of progressive MS – are we any closer?

Optimal Usage of Colistin: Are We Any Closer?

Despite being the mainstay of treatment for carbapenem-resistant gram-negative bacilli for more than a decade, optimal strategies for dosing and administration of colistin remain unclear. Colistin dosing regimens vary considerably throughout the world. In some instances, the total daily dose delivered varies 2-fold depending on geography. Compounding the issue is the fact that the majority of d...

Are we any closer to combating Ebola infections?

In March, 2009, a scientist working in a highcontainment laboratory in Germany pricked herself with a needle that had just been used to infect a mouse with the Ebola virus. Although rare, similar laboratory accidents with Ebola virus have been reported in the UK (1976), USA (2004), and Russia (2004), of which the one in Russia was fatal. Additionally, there have been at least three exposures to...

Schizophrenia pathophysiology: are we any closer to a complete model?

Schizophrenia, a severe brain disorder that involves hallucinations, disordered thinking and deficiencies in cognition, has been studied for decades in order to determine the early events that lead to this neurological disorder. In this review, we interpret the developmental and genetic models that have been proposed and treatment options associated with these models. Schizophrenia was initiall...

Why are we not getting any closer to preventing suicide?

Reporting rates of ectopic pregnancy: are we any closer to achieving consensus?

Calculating rates of ectopic pregnancy in a reliable and reproducible way can be challenging. To date, there is no consensus as to which denominators to use but the authors suggest using the total number of deliveries as a benchmark. In many developing countries where ectopic pregnancy is a major cause of maternal morbidity and mortality, standardisation of epidemiological data is arguably even...